Document Detail

Amino acid metabolism, branched-chain amino acid feeding and brain monoamine function.
MedLine Citation:
PMID:  9571706     Owner:  NLM     Status:  MEDLINE    
Although fatigue during prolonged exercise has traditionally been associated with peripheral factors relating to muscle metabolism, such as the depletion of muscle glycogen, more recent research has generated a renewed interest in amino acid metabolism per se and in the role of amino acids as precursors of brain neurotransmitter function. The concept of a 'central fatigue hypothesis' has done much to stimulate scientists to explore the functional role of the brain and CNS in the aetiology of the fatigue process. The concept has also generated a number of testable hypotheses by which it is possible to examine how the 'central' component of fatigue may act. The present review has attempted to bring together the current research in this area. There is good reason to believe that nutritional intervention may play an important role in relation to fatigue residing within the brain and CNS. Although an exciting possibility exists that nutritional manipulation may affect brain neurochemistry and ultimately sports performance, the experimental evidence to support this claim is, as yet, equivocal. A greater understanding of amino acid metabolism and, in particular, amino acid transport, will greatly improve future experimental designs used to test the efficacy of nutritional manipulation of amino acids and their effect on the central component of the fatigue process.
P M Jakeman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Proceedings of the Nutrition Society     Volume:  57     ISSN:  0029-6651     ISO Abbreviation:  Proc Nutr Soc     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-10     Completed Date:  1998-06-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7505881     Medline TA:  Proc Nutr Soc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
Department of Physical Education and Sport Sciences, University of Limerick, Republic of Ireland.
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MeSH Terms
Amino Acids / administration & dosage,  blood,  metabolism*
Biogenic Monoamines / metabolism*
Brain / metabolism*
Cross-Sectional Studies
Longitudinal Studies
Tryptophan / blood
Reg. No./Substance:
0/Amino Acids; 0/Biogenic Monoamines; 73-22-3/Tryptophan

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