| Amino acid levels in elderly nursing home residents. | |
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MedLine Citation:
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PMID: 2635018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have compared levels of albumin and serum amino acids in a group of 87 recent admissions to a nursing home, average age 83 years, with a group of healthy moderately old subjects, average age 69 years. We found that the nursing home group was characterized by decreased levels of albumin, by increased total levels of the measured amino acids, and by increased levels of the nonessential amino acids. In contrast, there were no significant group differences in the essential amino acids. Among the nursing home patients, there was a negative correlation between essential amino acids and disability, consistent with nutritional deficits in the more disabled patients, and a positive correlation between essential amino acids and subjective complaints of pain, suggesting that pain is associated with breakdown or mobilization of endogenous protein stores. Though the nursing home patients had decreased serum levels of tryptophan, there was no association between serum tryptophan or other variables that could be related to the availability of tryptophan for transport into brain, with ratings of either depression or pain. Glutamine levels were significantly increased in the nursing home residents, and among these patients they were positively correlated with measures of cognitive impairment. |
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Authors:
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I R Katz; E Friedman; P Parmelee; J Posner; C Muhly; W H Bridger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of geriatric psychiatry and neurology Volume: 2 ISSN: 0891-9887 ISO Abbreviation: J Geriatr Psychiatry Neurol Publication Date: 1989 Oct-Dec |
Date Detail:
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Created Date: 1990-06-13 Completed Date: 1990-06-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8805645 Medline TA: J Geriatr Psychiatry Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 215-22 Citation Subset: IM |
Affiliation:
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Division of Geriatric Psychiatry, Medical College of Pennsylvania, Philadelphia 19129. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living* Aged Amino Acids / blood* Amino Acids, Essential / blood Dementia / blood* Depressive Disorder / blood* Homes for the Aged* Humans Nursing Homes* Serum Albumin / metabolism Tryptophan / blood |
| Grant Support | |
ID/Acronym/Agency:
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MH40380/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Amino Acids, Essential; 0/Serum Albumin; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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