Document Detail


Amino acid levels in elderly nursing home residents.
MedLine Citation:
PMID:  2635018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have compared levels of albumin and serum amino acids in a group of 87 recent admissions to a nursing home, average age 83 years, with a group of healthy moderately old subjects, average age 69 years. We found that the nursing home group was characterized by decreased levels of albumin, by increased total levels of the measured amino acids, and by increased levels of the nonessential amino acids. In contrast, there were no significant group differences in the essential amino acids. Among the nursing home patients, there was a negative correlation between essential amino acids and disability, consistent with nutritional deficits in the more disabled patients, and a positive correlation between essential amino acids and subjective complaints of pain, suggesting that pain is associated with breakdown or mobilization of endogenous protein stores. Though the nursing home patients had decreased serum levels of tryptophan, there was no association between serum tryptophan or other variables that could be related to the availability of tryptophan for transport into brain, with ratings of either depression or pain. Glutamine levels were significantly increased in the nursing home residents, and among these patients they were positively correlated with measures of cognitive impairment.
Authors:
I R Katz; E Friedman; P Parmelee; J Posner; C Muhly; W H Bridger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of geriatric psychiatry and neurology     Volume:  2     ISSN:  0891-9887     ISO Abbreviation:  J Geriatr Psychiatry Neurol     Publication Date:    1989 Oct-Dec
Date Detail:
Created Date:  1990-06-13     Completed Date:  1990-06-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8805645     Medline TA:  J Geriatr Psychiatry Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
Affiliation:
Division of Geriatric Psychiatry, Medical College of Pennsylvania, Philadelphia 19129.
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MeSH Terms
Descriptor/Qualifier:
Activities of Daily Living*
Aged
Amino Acids / blood*
Amino Acids, Essential / blood
Dementia / blood*
Depressive Disorder / blood*
Homes for the Aged*
Humans
Nursing Homes*
Serum Albumin / metabolism
Tryptophan / blood
Grant Support
ID/Acronym/Agency:
MH40380/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Essential; 0/Serum Albumin; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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