Document Detail


Amino acid immunoreactivity in normal human retina and after brachytherapy.
MedLine Citation:
PMID:  23331319     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We localised amino acids in the mid-peripheral aged human retina and a retina that had undergone radiation treatment 10 years earlier. The distribution pattern of glutamate, γ-amino butyric acid (GABA), glycine, glutamine and taurine, reflected patterns established in the primate retina. The retina that had undergone radiation exposure displayed both anatomical and neurochemical remodelling. The proximal retina comprised around 40 to 45 per cent of the total retina and neuronal kinesis and aberrant neuronal projections were also present. Amino acid neurochemistry was strikingly different with Müller cells displaying GABA loading, glycinergic neurons displaced and displaying a very high level of glycine labelling. We conclude that radiation exposure triggered these changes in the human retina and likely reflects general remodelling of structure and function following ischaemic damage to endothelial cells.
Authors:
Clairton F de Souza; Monica L Acosta; Philip J Polkinghorne; Charles Nj McGhee; Michael Kalloniatis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Clinical & experimental optometry : journal of the Australian Optometrical Association     Volume:  -     ISSN:  1444-0938     ISO Abbreviation:  Clin Exp Optom     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703442     Medline TA:  Clin Exp Optom     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Clinical and Experimental Optometry © 2013 Optometrists Association Australia.
Affiliation:
Department of Ophthalmology, University of Auckland, Auckland, New Zealand; Department of Optometry and Vision Science, University of Auckland, Auckland, New Zealand; New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.
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