Document Detail

Amino acid concentrations in cerebrospinal fluid in presenile and senile dementia of Alzheimer type and multi-infarct dementia.
MedLine Citation:
PMID:  2686573     Owner:  NLM     Status:  MEDLINE    
Free amino acid levels were measured in cerebrospinal fluid (CSF) from demented patients (D, n = 30) suffering from presenile and senile dementia of Alzheimer type (PDAT, n = 7; SDAT, n = 9), multi-infarct dementia (MID, n = 14) and a reference sample group consisting of young neurotic patients (R, n = 16). Comparing the amino acid levels in the dementia subgroups, significantly higher alanine, methionine, phenylalanine and tyrosine levels were found both in MID and SDAT vs. PDAT. No difference was seen between SDAT and MID. Compared to the reference sample group, higher glycine levels were found in each dementia subgroup; higher alanine, methionine and ornithine levels in MID, and SDAT; and higher phenylalanine levels in MID. In PDAT the level of tyrosine was lower. Coefficients of correlation were calculated between amino acid levels and age, and the findings in the reference sample groups were divergent from those observed in dementia. The differences observed are discussed in terms of amino acid, carbohydrate and neurotransmitter metabolism.
I Degrell; K Hellsing; E Nagy; F Niklasson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Archives of gerontology and geriatrics     Volume:  9     ISSN:  0167-4943     ISO Abbreviation:  Arch Gerontol Geriatr     Publication Date:    1989 Sep-Oct
Date Detail:
Created Date:  1990-01-03     Completed Date:  1990-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214379     Medline TA:  Arch Gerontol Geriatr     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  123-35     Citation Subset:  IM    
Department of Neurology and Psychiatry, University Medical School of Debrecen, Hungary.
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MeSH Terms
Age Factors
Aged, 80 and over
Alzheimer Disease / cerebrospinal fluid*
Amino Acids / cerebrospinal fluid*
Dementia, Multi-Infarct / cerebrospinal fluid*
Middle Aged
Sex Factors
Reg. No./Substance:
0/Amino Acids

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