Document Detail


Amino acid concentrations in cerebrospinal fluid and plasma in Alzheimer's disease and healthy control subjects.
MedLine Citation:
PMID:  2078309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebrospinal fluid (CSF) and plasma levels of 18 amino acids were studied in 22 subjects with dementia of the Alzheimer type (DAT) and in 11 healthy volunteers with no clinical or family history of dementia. Significant decreases of plasma taurine and glutamate were seen in the DAT cases compared with the controls. The CSF concentrations of glycine, leucine and valine were also significantly reduced in the DAT cases. Furthermore, in the DAT cases significant decreases were observed in the ratio between CSF and plasma (CSF/P) levels for alanine, glutamine, glycine, phenylalanine and valine, when compared with controls. In the DAT group there were significant correlations between behaviour and CSF glutamine; memory and cognitive functions and CSF valine; copying ability and CSF glutamate. CSF/P ratios of glutamine and glutamate correlated with behaviour and copying performances, respectively. The results of this study provide further evidence for a disruption of amino acid metabolism in DAT.
Authors:
H Basun; L G Forssell; O Almkvist; R F Cowburn; R Eklöf; B Winblad; L Wetterberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission. Parkinson's disease and dementia section     Volume:  2     ISSN:  0936-3076     ISO Abbreviation:  J Neural Transm Park Dis Dement Sect     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-01     Completed Date:  1991-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8914371     Medline TA:  J Neural Transm Park Dis Dement Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  295-304     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Karolinska Institute, S:t Göran's Hospital, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / blood,  cerebrospinal fluid,  metabolism*
Amino Acids / analysis*
Female
Humans
Male
Middle Aged
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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