Document Detail

Amino acid concentration in plasma after gastro-intestinal, intraportal and intravenous administration of crystalline amino acids. Preliminary report.
MedLine Citation:
PMID:  822665     Owner:  NLM     Status:  MEDLINE    
In three series of 3 dogs each a solution of crystalline amino acids (Vamin) was given by different routes: gastro-intestinally, intraportally of intravenously. The infusion period was 3 hours and the administered amount 3 g per kg body weight. The amino acid concentration in plasma from different sites of the circulation was analysed before, during and after the infusion. In the series of intraportal and of intravenous infusion blood was taken from the hepatic vein and a peripheral vein and in the gastro-intestinal series from the portal vein as well. Tryptophan and tyrosine increased very slightly in all the series and tyrosine also showed a tendency to decrease during the infusion after an initial rise. Glutamic acid and aspartic acid increased quite markedly when given intravenously and intraportally, but there were only very small blood-level changes at gastro-intestinal administration. The intestinal mucosa seems to play an important role in amino acid metabolism. The remaining 14 of the 18 amino acids given showed approximately the same pattern of blood-level changes during and after the infusion.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta chirurgica Scandinavica     Volume:  142     ISSN:  0001-5482     ISO Abbreviation:  Acta Chir Scand     Publication Date:  1976  
Date Detail:
Created Date:  1976-10-29     Completed Date:  1976-10-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906530     Medline TA:  Acta Chir Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  279-84     Citation Subset:  IM    
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MeSH Terms
Amino Acids / administration & dosage,  blood*,  metabolism
Aspartic Acid / blood,  metabolism
Glutamates / blood,  metabolism
Intestinal Mucosa / metabolism
Leucine / blood,  metabolism
Liver / metabolism
Parenteral Nutrition*
Portal Vein
Tryptophan / blood,  metabolism
Tyrosine / blood,  metabolism
Reg. No./Substance:
0/Amino Acids; 0/Glutamates; 55520-40-6/Tyrosine; 56-84-8/Aspartic Acid; 61-90-5/Leucine; 73-22-3/Tryptophan

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