| Amino acid composition in parenteral nutrition: what is the evidence? | |
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MedLine Citation:
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PMID: 21076291 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Complete parenteral nutrition solutions contain mixed amino acid products providing all nine essential amino acids and a varying composition of nonessential amino acids. Relatively little rigorous comparative efficacy research on altered parenteral nutrition amino acid composition has been published in recent years. RECENT FINDINGS: Limited data from randomized, double-blind, adequately powered clinical trials to define optimal doses of total or individual amino acids in parenteral nutrition are available. An exception is the growing number of studies on the efficacy of glutamine supplementation of parenteral nutrition or given as a single parenteral agent. Parenteral glutamine appears to confer benefit in selected patients; however, additional data to define optimal glutamine dosing and the patient subgroups who may most benefit from this amino acid are needed. Although some promising studies have been published, little data are available in the current era of nutrition support on the clinical efficacy of altered doses of arginine, branched chain amino acids, cysteine, or taurine supplementation of parenteral nutrition. SUMMARY: Despite routine use of parenteral nutrition, surprisingly little clinical efficacy data are available to guide total or specific amino acid dosing in adult and pediatric patients requiring this therapy. This warrants increased attention by the research community and funding agencies to better define optimal amino acid administration strategies in patient subgroups requiring parenteral nutrition. |
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Authors:
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Shadi S Yarandi; Vivian M Zhao; Gautam Hebbar; Thomas R Ziegler |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current opinion in clinical nutrition and metabolic care Volume: 14 ISSN: 1473-6519 ISO Abbreviation: Curr Opin Clin Nutr Metab Care Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-02-15 Completed Date: 2011-08-24 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 9804399 Medline TA: Curr Opin Clin Nutr Metab Care Country: England |
Other Details:
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Languages: eng Pagination: 75-82 Citation Subset: IM |
Affiliation:
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Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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administration & dosage,
therapeutic use* Glutamine / therapeutic use Humans Parenteral Nutrition Solutions / chemistry* Parenteral Nutrition, Total* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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K24 RR023356/RR/NCRR NIH HHS; K24 RR023356-05/RR/NCRR NIH HHS; U01 DK069322/DK/NIDDK NIH HHS; UL1 RR025008/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Parenteral Nutrition Solutions; 56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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