Document Detail

Amino acid codes in mitochondria as possible clues to primitive codes.
MedLine Citation:
PMID:  6801266     Owner:  NLM     Status:  MEDLINE    
Differences between mitochondrial codes and the universal code indicate that an evolutionary simplification has taken place, rather than a return to a more primitive code. However, these differences make it evident that the universal code is not the only code possible, and therefore earlier codes may have differed markedly from the previous code. The present universal code is probably a "frozen accident." The change in CUN codons from leucine to threonine (Neurospora vs. yeast mitochondria) indicates that neutral or near-neutral changes occurred in the corresponding proteins when this code change took change took place, caused presumably by a mutation in a tRNA gene.
T H Jukes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of molecular evolution     Volume:  18     ISSN:  0022-2844     ISO Abbreviation:  J. Mol. Evol.     Publication Date:  1981  
Date Detail:
Created Date:  1982-05-21     Completed Date:  1982-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0360051     Medline TA:  J Mol Evol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  15-7     Citation Subset:  IM; S    
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MeSH Terms
Amino Acids / metabolism
Anticodon / physiology
Base Sequence
DNA, Mitochondrial*
Genetic Code*
Leucine / metabolism
Neurospora / genetics
RNA, Transfer / physiology
Threonine / metabolism
Yeasts / genetics
Reg. No./Substance:
0/Amino Acids; 0/Anticodon; 0/DNA, Mitochondrial; 61-90-5/Leucine; 72-19-5/Threonine; 9014-25-9/RNA, Transfer

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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