| Amino acid changes in thiamine-deficient encephalopathy: some implications for the pathogenesis of Friedreich's ataxia. | |
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MedLine Citation:
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PMID: 487314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thiamine-deficient encephalopathy in the rat is characterized by ataxic gait, loss of righting reflex and curvature of the spine. Neurochemical changes include a diminished activity of cerebral pyruvate decarboxylase leading to abnormal pyruvate oxidation. The present study shows that this defective pyruvate oxidation produces a significant depletion of three important amino acid neurotransmitters, namely gamma aminobutyric acid (GABA), glutamic acid, and aspartic acid. Such changes could lead to severe neuronal dysfunction and the observed neurological symptoms of thiamine deficiency. Some implications for the pathogenesis of Friedreich's ataxia are discussed. |
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Authors:
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R F Butterworth; E Hamel; F Landreville; A Barbeau |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 6 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 1979 May |
Date Detail:
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Created Date: 1979-12-27 Completed Date: 1979-12-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: CANADA |
Other Details:
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Languages: eng Pagination: 217-22 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Aspartic Acid / metabolism Brain / metabolism Brain Diseases / etiology, metabolism* Friedreich Ataxia / metabolism* Glutamates / metabolism Glutamine / metabolism Glycine / metabolism Male Pyrithiamine Rats Retina / metabolism Spinal Cord / metabolism Taurine / metabolism Thiamine Deficiency / complications, metabolism* gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Glutamates; 107-35-7/Taurine; 534-64-5/Pyrithiamine; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 56-84-8/Aspartic Acid; 56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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