Document Detail


Amino acid carriers at maternal and fetal surfaces of the placenta by single circulation paired-tracer dilution. Kinetics of phenylalanine transport.
MedLine Citation:
PMID:  7356999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The unidirectional uptake into the trophoblast of L-leucine, L-isoleucine, L-phenylalanine, L-tryptophan, L-methionine and L-tyrosine from either the maternal or fetal circulations of an isolated dually-perfused guinea-pig placenta was studied using a single circulation paired-tracer dilution technique. Significant and equal uptakes were found on both sides. L-Phenylalanine uptake kinetics on the fetal side indicated an apparent Km of 17.0 mM and a V of 8.2 mumol/min per g.
Authors:
D L Yudilevich; B M Eaton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  596     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-05-14     Completed Date:  1980-05-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Animals
Female
Glucose / metabolism
Guinea Pigs
Kinetics
Maternal-Fetal Exchange*
Perfusion
Phenylalanine / metabolism*
Placenta / metabolism*
Pregnancy
Chemical
Reg. No./Substance:
0/Amino Acids; 50-99-7/Glucose; 63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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