| Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agents. | |
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MedLine Citation:
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PMID: 19932967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A diverse group of novel medium ring heterocycles derived from naturally abundant proteinogenic amino acids were evaluated for their potency towards antithrombotic activity. The more potent benzofused oxazepine and oxazocine scaffolds were diversified by incorporating different amino acids at the position number 3. Further the effect of ring size has also been taken into account and it was observed that the eight-membered oxazocines ane more potent compared to the corresponding oxazepines. |
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Authors:
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Jitendra Kumar Mishra; Krishnananda Samanta; Manish Jain; Madhu Dikshit; Gautam Panda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-30 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 244-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, UP, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry* Benzodiazepines / chemistry Fibrinolytic Agents / chemical synthesis, chemistry*, pharmacology Heterocyclic Compounds, 2-Ring / chemical synthesis, chemistry*, pharmacology Oxazepines / chemistry Oxazocines / chemistry Stereoisomerism Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Fibrinolytic Agents; 0/Heterocyclic Compounds, 2-Ring; 0/Oxazepines; 0/Oxazocines; 12794-10-4/Benzodiazepines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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