Document Detail


Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agents.
MedLine Citation:
PMID:  19932967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A diverse group of novel medium ring heterocycles derived from naturally abundant proteinogenic amino acids were evaluated for their potency towards antithrombotic activity. The more potent benzofused oxazepine and oxazocine scaffolds were diversified by incorporating different amino acids at the position number 3. Further the effect of ring size has also been taken into account and it was observed that the eight-membered oxazocines ane more potent compared to the corresponding oxazepines.
Authors:
Jitendra Kumar Mishra; Krishnananda Samanta; Manish Jain; Madhu Dikshit; Gautam Panda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-30
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  20     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  244-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, UP, India.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*
Benzodiazepines / chemistry
Fibrinolytic Agents / chemical synthesis,  chemistry*,  pharmacology
Heterocyclic Compounds, 2-Ring / chemical synthesis,  chemistry*,  pharmacology
Oxazepines / chemistry
Oxazocines / chemistry
Stereoisomerism
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Fibrinolytic Agents; 0/Heterocyclic Compounds, 2-Ring; 0/Oxazepines; 0/Oxazocines; 12794-10-4/Benzodiazepines

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