Document Detail

Amino acid analysis demonstrates that increased plasma free tryptophan causes the increase of brain tryptophan during exercise in the rat.
MedLine Citation:
PMID:  3083049     Owner:  NLM     Status:  MEDLINE    
Rats were trained to run on a horizontal treadmill for 2 h at 20 m/min. This activity considerably increased plasma free tryptophan (TRP) (+70%) but did not alter plasma total TRP levels and had little or no effect on plasma concentrations of the other large neutral amino acids (LNAAs) that compete with TRP for entry into the brain. Brain TRP levels increased by 80%. The only other brain LNAA to be affected by exercise was threonine, which rose moderately. The results indicate that increased plasma free TRP was specifically responsible for the increase of brain TRP after 2 h of exercise. Brain lysine was also increased whereas glycine, alanine, and gamma-aminobutyric acid were decreased. The differences between the present findings and those previously obtained following 2 h immobilization stress are discussed.
F Chaouloff; G A Kennett; B Serrurrier; D Merino; G Curzon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  46     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-05-19     Completed Date:  1986-05-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1647-50     Citation Subset:  IM    
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MeSH Terms
Alanine / metabolism
Amino Acids / blood,  metabolism*
Brain / metabolism*
Glycine / metabolism
Lysine / metabolism
Physical Exertion*
Rats, Inbred Strains
Stress, Physiological / metabolism
Tryptophan / blood,  metabolism*
gamma-Aminobutyric Acid / metabolism
Reg. No./Substance:
0/Amino Acids; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 56-41-7/Alanine; 56-87-1/Lysine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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