| Amino acid alcohols: growth inhibition and induction of differentiated features in melanoma cells. | |
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MedLine Citation:
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PMID: 8099846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of a series of D- and L-amino acid alcohols on the proliferation and phenotypic expression of B16 mouse melanoma cells were evaluated. B16 melanoma cells were incubated for different time intervals in the presence of D- or L-phenylalaninol (PHE), D- or L-alaninol (AL), D- or L-leucinol (LE), L-histidinol (HIS), L-tyrosinol (TYR) and L-methioninol (MET). All agents, including the D or L configuration, induced an anti-proliferative effect, although of considerably different magnitude. D-PHE was the most active growth inhibitor. The growth inhibitory effects were accompanied by phenotypic alterations, which included morphological changes and enhancement in the activities of NADPH cytochrome c reductase and tau-glutamyl transpeptidase. These phenotypic alterations correlated with the growth inhibitory effects of the different agents and seem to reflect a higher differentiated state. |
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Authors:
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O Landau; L Wasserman; A A Deutsch; R Reiss; H Panet; A Novogrodsky; J Nordenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer letters Volume: 69 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-07-19 Completed Date: 1993-07-19 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 203-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, Beilinson Medical Center, Petah Tiqva, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Alcohols
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pharmacology* Animals Cell Division / drug effects Enzyme Induction / drug effects Melanoma, Experimental / enzymology, pathology* Mice NADPH-Ferrihemoprotein Reductase / biosynthesis Phenotype gamma-Glutamyltransferase / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Amino Alcohols; EC 1.6.2.4/NADPH-Ferrihemoprotein Reductase; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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