Document Detail

Amino-terminal pro-brain natriuretic peptide levels in hypertensive disorders complicating pregnancy.
MedLine Citation:
PMID:  20701470     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is synthesized in cardiac ventricles in response to volume expansion. This study evaluated NT-proBNP levels to determine the clinical correlation with the severity of hypertensive disorders complicating pregnancy.
METHODS: NT-proBNP levels of 95 pregnant women (severe preeclampsia [n = 26], mild preeclampsia [n = 15], gestational hypertension [n = 9], and healthy controls [n = 45]) were determined using an electrochemiluminescence immunoassay.
RESULTS: Comparisons of the mean values of NT-proBNP levels in the different groups were significantly different, as follows: 1766.43 ± 4197.39 pg/mL (median, 339.8 pg/mL) in severe preeclampsia, 214.97 ± 226.35 pg/mL (median, 152.3 pg/mL) in mild preeclampsia, 39.75 ± 24.85 pg/mL (median, 34.09 pg/mL) in gestational hypertension, and 78.78 ± 81.56 pg/mL (median, 48.54 pg/mL) in the healthy controls. The NT-proBNP levels of the patients with mild and severe preeclampsia were significantly higher than in the patients with gestational hypertension and the healthy control patients. There was no significant difference in NT-proBNP levels between patients with mild and severe preeclampsia (p = 0.17).
CONCLUSION: In patients with mild and severe preeclampsia, NT-proBNP levels were elevated. This may reflect ventricular stress and/or subclinical cardiac dysfunction associated with preeclampsia.
Won Joon Seong; Seung Chan Kim; Dae Gy Hong; Tae Bon Koo; Il Soo Park
Publication Detail:
Type:  Journal Article     Date:  2010-08-11
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  30     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-11     Completed Date:  2012-02-13     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  287-94     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Hypertension, Pregnancy-Induced / blood*,  diagnosis
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Pre-Eclampsia / blood,  diagnosis
Severity of Illness Index*
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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