Document Detail

Amino acids from Mytilus galloprovincialis (L.) and Rapana venosa molluscs accelerate skin wounds healing via enhancement of dermal and epidermal neoformation.
MedLine Citation:
PMID:  20087635     Owner:  NLM     Status:  MEDLINE    
Wound healing consists of re-epithelialization, contraction and formation of granulation and scar tissue. Amino acids from proteins are involved in these events, but their exact roles are not well understood. The present study was undertaken to investigate the anti-inflammatory effects of some amino acids from two molluscs, Mytilus galloprovincialis (L.) (Mediterranean mussel) and Rapana venosa (hard shell-clam) employed in induced skin burn injuries in Wistar rats. The treatment was evaluated in terms of essential amino acids composition which rendered the extracts very efficient in healing skin burns. The healing process was examined by periodic acid Schiff's, Verhoeff's Van Gieson and immunohistochemistry stains for collagen IV, CD 34 and CD 117 antibodies. According to the obtained results, as expressed by histological studies, the most abundant blood vessels, collagen fibres, basal and stem cells were found only for treated animals with amino acids from Rapana venosa extracts. The rich composition of amino acids from the two molluscs merits consideration as therapeutic agents in the treatment of skin burns.
Diana L Badiu; Rafael Luque; Elena Dumitrescu; Anca Craciun; Danut Dinca
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The protein journal     Volume:  29     ISSN:  1875-8355     ISO Abbreviation:  Protein J.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101212092     Medline TA:  Protein J     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  81-92     Citation Subset:  IM    
Department of Biology-Biochemistry, Faculty of Natural and Agricultural Sciences, Ovidius University of Constanta, 124 Mamaia Blvd., 900527, Constanta, Romania.
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MeSH Terms
Amino Acids / pharmacology*,  therapeutic use
Bivalvia / chemistry*
Burns / drug therapy,  pathology
Mytilus / chemistry*
Random Allocation
Rats, Wistar
Regeneration* / drug effects,  physiology
Skin* / drug effects,  injuries,  metabolism
Tissue Extracts / chemistry*
Wound Healing / drug effects*
Reg. No./Substance:
0/Amino Acids; 0/Tissue Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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