Document Detail


Amino acids and TOR signaling promote prothoracic gland growth and the initiation of larval molts in the tobacco hornworm Manduca sexta.
MedLine Citation:
PMID:  22984508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Molting in arthropods is orchestrated by a series of endocrine changes that occur towards the end of an instar. However, little is understood about the mechanisms that trigger these endocrine changes. Here, nutritional inputs were manipulated to investigate the minimal nutritional inputs required for a Manduca sexta larva to initiate a molt. Amino acids were found to be necessary for a larva to molt, indicating the involvement of an amino acid sensitive pathway. Feeding rapamycin, an inhibitor of the target of rapamycin (TOR) signaling, delayed the onset of a molt and resulted in abnormally larger larvae. Rapamycin also suppressed the growth of the prothoracic glands relative to the whole body growth, and this was accompanied by suppression of ecdysone production and secretion. Higher doses of rapamycin also slowed the growth rate, indicating that TOR signaling also plays a role in systemic growth. TOR signaling therefore couples the nutritional status of the larva to the endocrine system to regulate the timing of a molt.
Authors:
Karen Kemirembe; Kate Liebmann; Abigail Bootes; Wendy A Smith; Yuichiro Suzuki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-12
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-17     Completed Date:  2013-03-12     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e44429     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Wellesley College, Wellesley, Massachusetts, United States of America.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Animal Feed
Animal Nutritional Physiological Phenomena
Animals
Ecdysterone / pharmacology
Endocrine System
Gene Expression Regulation, Developmental*
Larva / physiology*
Manduca / metabolism*
Models, Biological
Molting / physiology
Signal Transduction
Sirolimus / pharmacology*
Sucrose / pharmacology
TOR Serine-Threonine Kinases / metabolism*
Chemical
Reg. No./Substance:
0/Amino Acids; 5289-74-7/Ecdysterone; 53123-88-9/Sirolimus; 57-50-1/Sucrose; EC 2.7.1.1/TOR Serine-Threonine Kinases
Comments/Corrections

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