Document Detail

Amino Acid Metabolism Related to Immune Tolerance by MDSCs.
MedLine Citation:
PMID:  22587019     Owner:  NLM     Status:  In-Data-Review    
Myeloid-derived suppressor cells (MDSCs) are present in most cancer patients. Due to their significant role in blocking immune responses, MDSCs are strategic obstacles to immunotherapy that require activation of the host's cell-mediated and innate immune responses. Following a brief description of the immunosuppressive MDSCs, the authors review the discovered mechanisms of amino acid metabolism that MDSCs use to suppress the activation of T cells. Given the heterogeneity of MDSCs and the variety of suppressive mechanisms employed by MDSCs, it is essential to understand which group of these cells and mechanisms are dominant.
Baohong Yang; Xiaomeng Wang; Xiubao Ren
Related Documents :
22712839 - Multiple signal transduction pathways are involved in g(2)/m growth arrest and apoptosi...
22728359 - Aqueous fraction of nephelium ramboutan-ake rind induces mitochondrial-mediated apoptos...
22301689 - Bim regulates b-cell receptor-mediated apoptosis in the presence of cd40 signaling in c...
22354779 - Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulate...
2188579 - Interactions between the brain and the immune system.
20727229 - The role of inflammation in icu-acquired weakness.
7526859 - Apoptosis in l929 cells expressing a cd40/fas chimeric receptor: dissociation of stimul...
21123169 - Surfactant protein a (sp-a)-mediated clearance of staphylococcus aureus involves bindin...
24738849 - Immune-regulation and anti-inflammatory effects of isogarcinol extracted from garcinia ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International reviews of immunology     Volume:  31     ISSN:  1563-5244     ISO Abbreviation:  Int. Rev. Immunol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712260     Medline TA:  Int Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
1Department of Biotherapy, Tianjin Cancer Institute and Hospital, Tianjin Medical University.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  In this issue of the International Reviews of Immunology.
Next Document:  The interplay between diet and emerging allergy: what can we learn from indigenous australians?