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Amino Acid Metabolism Related to Immune Tolerance by MDSCs.
MedLine Citation:
PMID:  22587019     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Myeloid-derived suppressor cells (MDSCs) are present in most cancer patients. Due to their significant role in blocking immune responses, MDSCs are strategic obstacles to immunotherapy that require activation of the host's cell-mediated and innate immune responses. Following a brief description of the immunosuppressive MDSCs, the authors review the discovered mechanisms of amino acid metabolism that MDSCs use to suppress the activation of T cells. Given the heterogeneity of MDSCs and the variety of suppressive mechanisms employed by MDSCs, it is essential to understand which group of these cells and mechanisms are dominant.
Authors:
Baohong Yang; Xiaomeng Wang; Xiubao Ren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International reviews of immunology     Volume:  31     ISSN:  1563-5244     ISO Abbreviation:  Int. Rev. Immunol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712260     Medline TA:  Int Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Affiliation:
1Department of Biotherapy, Tianjin Cancer Institute and Hospital, Tianjin Medical University.
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