Document Detail

Amino Acid Homeostasis and Chronological Longevity in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  22094422     Owner:  NLM     Status:  In-Data-Review    
Understanding how non-dividing cells remain viable over long periods of time, which may be decades in humans, is of central importance in understanding mechanisms of aging and longevity. The long-term viability of non-dividing cells, known as chronological longevity, relies on cellular processes that degrade old components and replace them with new ones. Key among these processes is amino acid homeostasis. Amino acid homeostasis requires three principal functions: amino acid uptake, de novo synthesis, and recycling. Autophagy plays a key role in recycling amino acids and other metabolic building blocks, while at the same time removing damaged cellular components such as mitochondria and other organelles. Regulation of amino acid homeostasis and autophagy is accomplished by a complex web of pathways that interact because of the functional overlap at the level of recycling. It is becoming increasingly clear that amino acid homeostasis and autophagy play important roles in chronological longevity in yeast and higher organisms. Our goal in this chapter is to focus on mechanisms and pathways that link amino acid homeostasis, autophagy, and chronological longevity in yeast, and explore their relevance to aging and longevity in higher eukaryotes.
John P Aris; Laura K Fishwick; Michelle L Marraffini; Arnold Y Seo; Christiaan Leeuwenburgh; William A Dunn
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sub-cellular biochemistry     Volume:  57     ISSN:  0306-0225     ISO Abbreviation:  Subcell. Biochem.     Publication Date:  2012  
Date Detail:
Created Date:  2011-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0316571     Medline TA:  Subcell Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  161-86     Citation Subset:  IM    
Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL, 32610-0235, USA,
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