Document Detail

Amino acid bound surfactants: a new synthetic family of polymeric monoliths opening up possibilities for chiral separations in capillary electrochromatography.
MedLine Citation:
PMID:  22607448     Owner:  NLM     Status:  MEDLINE    
By combining a novel chiral amino-acid surfactant containing an acryloyl amide tail, a carbamate linker, and a leucine headgroup of different chain lengths with a conventional cross-linker and a polymerization technique, a new "one-pot" synthesis for the generation of amino-acid based polymeric monolith is realized. The method promises to open up the discovery of an amino-acid based polymeric monolith for chiral separations in capillary electrochromatography (CEC). The possibility of enhanced chemoselectivity for simultaneous separation of ephedrine and pseudoephedrine containing multiple chiral centers and the potential use of this amino-acid surfactant bound column for CEC and CEC coupled to mass spectrometric detection are demonstrated.
Jun He; Xiaochun Wang; Mike Morill; Shahab A Shamsi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-07
Journal Detail:
Title:  Analytical chemistry     Volume:  84     ISSN:  1520-6882     ISO Abbreviation:  Anal. Chem.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-22     Completed Date:  2012-10-18     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5236-42     Citation Subset:  IM    
Center of Diagnostics and Therapeutics, Georgia State University, 50 Decatur Street, Atlanta, Georgia 30303, USA.
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MeSH Terms
Acetonitriles / chemistry
Amides / chemistry
Amino Acids / chemistry*
Capillary Electrochromatography / methods*
Carbamates / chemistry
Ephedrine / chemistry,  isolation & purification
Ethylamines / chemistry
Polymers / chemical synthesis*,  chemistry*
Pseudoephedrine / chemistry,  isolation & purification
Reproducibility of Results
Surface-Active Agents / chemical synthesis*,  chemistry*
beta-Cyclodextrins / chemistry
Grant Support
Reg. No./Substance:
0/Acetonitriles; 0/Amides; 0/Amino Acids; 0/Carbamates; 0/Ethylamines; 0/Polymers; 0/Surface-Active Agents; 0/beta-Cyclodextrins; 299-42-3/Ephedrine; 90-82-4/Pseudoephedrine; VOU728O6AY/triethylamine; Z072SB282N/acetonitrile

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