| Amino Acid and Acylcarnitine Profiles in Premature Neonates: A Pilot Study. | |
| | |
MedLine Citation:
|
PMID: 23404695 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the longitudinal changes in amino acid (AA) and acylcarnitine (AC) profiles of preterm neonates over the first 2 wk of life, and to detect any significant deviation from full term values that requires change of cut-off values used for detection of metabolic disorders in preterm neonates. METHODS: This observational analytical longitudinal study was conducted on 131 premature neonates (gestational age ranged from 27 to 36 wk) and 143 healthy full-term neonates. Dried blood spots were taken on the 5th and 14th postnatal day from the premature neonates and on day 5 from full term neonates for neonatal screening. Samples were analyzed for AA and AC using tandem mass spectrometer. RESULTS: Most AA significantly decreased on day 14 compared to day 5 among preterm neonates (p < 0.05). The combined values of total carnitine (TC), total acylcarnitine (tAC) and short-chain acylcarnitines on day 5 among preterm neonates were statistically significantly higher compared to the day 14 sample (p 0.0001), whereas no statistically significant difference was found regarding the values of medium-, long-chain acylcarnitines, tAC/FC, and FC/TC (p > 0.05). The levels of AA of preterm neonates were statistically significantly higher than that of the controls (p < 0.05). The values of TC, tAC, short-, medium- and long-chain acylcarnitines, were significantly higher than those of the controls (p < 0.05). The reference ranges for preterm neonates were determined using the 1st and 99.9th percentiles. CONCLUSIONS: AA and AC showed an age-related distribution of their concentrations. This underlines the importance of using appropriate reference values when working with a prematurely born population. |
| | |
Authors:
|
Iman Mandour; Dina El Gayar; Maha Amin; Tarek Mohamed Farid; Aliaa Adel Ali |
Related Documents
:
|
16905785 - Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus i... 20300545 - Evidence for vertical transmission of hpv from mothers to infants. 21948025 - Continuous glucose monitoring and retinopathy of prematurity. 11955535 - Efficacy of three short-course regimens of zidovudine and lamivudine in preventing earl... 16905785 - Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus i... 18469055 - Effects of late introduction of sows to two farrowing environments on the progress of f... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-2-13 |
Journal Detail:
|
Title: Indian journal of pediatrics Volume: - ISSN: 0973-7693 ISO Abbreviation: Indian J Pediatr Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-2-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Giza, Egypt. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitiz...
Next Document: Determinants of Childhood Obesity: Need for a Trans-Sectoral Convergent Approach.