Document Detail


Aminative umpolung synthesis of aryl vicinal diamines from aromatic aldehydes.
MedLine Citation:
PMID:  24742159     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In this paper an aminative umpolung synthesis of aryl vicinal diamines from aldehydes and N-Ts imines is described. Electrophilic aromatic aldehydes were smoothly converted into delocalized 2-azaallylanions via condensation with 2,2-diphenylglycine in methanol and subsequent decarboxylation in THF and underwent further reaction with N-Ts imines to give a variety of 1,2-diamine derivatives in good yields with high syn/anti diastereoselectivity.
Authors:
Xuliang Liu; Ang Gao; Lei Ding; Juan Xu; Baoguo Zhao
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Publication Detail:
Type:  Journal Article     Date:  2014-04-07
Journal Detail:
Title:  Organic letters     Volume:  16     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2118-21     Citation Subset:  IM    
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