Document Detail

Aminaphtone in idiopathic cyclic oedema syndrome.
MedLine Citation:
PMID:  18467619     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Idiopathic cyclic oedema syndrome is a group of clinical conditions that exhibit a vascular capillary hyperpermeability accompanied by oedema caused by the interstitial retention of fluid. The objective of the current study was to evaluate the efficacy of aminaphtone in the treatment of idiopathic cyclic oedema.
METHODS: A total of 15 female patients with clinical diagnosis of idiopathic cyclic oedema and aged between 22 and 49 years and a mean of 37.7 years were evaluated. After diagnosis, the patients were submitted to lower limb volumetry and asked to record the weight in the morning and evening at fixed times. One tablet of aminaphtone was prescribed every 8 h and on the fifth day the patients were reassessed. Percentages and the paired t-test were utilized for statistical analysis, with an alpha error of 5% considered acceptable (P value <0.05).
RESULTS: A significant reduction in limb size was detected after treatment using aminaphtone (P value <0.0001) with losses between 9 g and 370 g, and an average loss of 116.9 g. Variations in weights in the morning and evening were significant (P value <0.00001) with a maximum difference of 3 kg and a minimum of 120 g. Improvements were reported for 70% of patients.
CONCLUSION: Aminaphtone is efficacious in the reduction of oedema in patients with idiopathic cyclic oedema.
J M Pereira de Godoy
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Phlebology / Venous Forum of the Royal Society of Medicine     Volume:  23     ISSN:  0268-3555     ISO Abbreviation:  Phlebology     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-08-22     Revised Date:  2014-08-08    
Medline Journal Info:
Nlm Unique ID:  9012921     Medline TA:  Phlebology     Country:  England    
Other Details:
Languages:  eng     Pagination:  118-9     Citation Subset:  IM    
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MeSH Terms
4-Aminobenzoic Acid / administration & dosage
Body Weight
Capillary Permeability
Circadian Rhythm*
Edema / drug therapy*,  etiology,  metabolism
Extracellular Fluid / metabolism
Middle Aged
Treatment Outcome
Reg. No./Substance:
0/para-Aminobenzoates; 03JLX11PE9/aminaftone; TL2TJE8QTX/4-Aminobenzoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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