| Amiloride inhibition of Na+-entry into corneal endothelium. | |
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MedLine Citation:
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PMID: 4011390 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amiloride in 10(-3) M concentration inhibits incompletely the short circuit current and active potential difference across the bovine corneal endothelium in vitro. The drug effect is reversible and unilateral, e.g. the drug is effective only from the aqueous side. The amiloride effect is compared to the effect of ouabain, nystatin and vasopressin on the same electrical parameters. The effect of these drugs support a model for active Na+ transport across the corneal endothelium with two separate pathways for Na+ transport - one for extrusion and one for reentry. |
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Authors:
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A Midelfart; S K Ratkje |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 403 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-08-12 Completed Date: 1985-08-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 377-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amiloride
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pharmacology* Animals Cattle Cornea / drug effects, metabolism* Corneal Stroma / drug effects Electric Conductivity Electrophysiology Endothelium / metabolism Ouabain / pharmacology Pyrazines / pharmacology* Sodium / antagonists & inhibitors*, metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Pyrazines; 2609-46-3/Amiloride; 630-60-4/Ouabain; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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