Document Detail

Amiloride-sensitive and amiloride-insensitive responses to NaCl + acid mixtures in hamster chorda tympani nerve.
MedLine Citation:
PMID:  22451526     Owner:  NLM     Status:  MEDLINE    
Component signaling in taste mixtures containing both beneficial and dangerous chemicals depends on peripheral processing. Unidirectional mixture suppression of chorda tympani (CT) nerve responses to sucrose by quinine and acid is documented for golden hamsters (Mesocricetus auratus). To investigate mixtures of NaCl and acids, we recorded multifiber responses to 50 mM NaCl, 1 and 3 mM citric acid and acetic acid, 250 μM citric acid, 20 mM acetic acid, and all binary combinations of each acid with NaCl (with and without 30 μM amiloride added). By blocking epithelial Na(+) channels, amiloride treatment separated amiloride-sensitive NaCl-specific responses from amiloride-insensitive electrolyte-generalist responses, which encompass all of the CT response to the acids as well as responses to NaCl. Like CT sucrose responses, the amiloride-sensitive NaCl responses were suppressed by as much as 50% by citric acid (P = 0.001). The amiloride-insensitive electrolyte-generalist responses to NaCl + acid mixtures approximated the sum of NaCl and acid component responses. Thus, although NaCl-specific responses to NaCl were weakened in NaCl-acid mixtures, electrolyte-generalist responses to acid and NaCl, which tastes KCl-like, were transmitted undiminished in intensity to the central nervous system. The 2 distinct CT pathways are consistent with known rodent behavioral discriminations.
Bradley K Formaker; Thomas P Hettinger; Lawrence D Savoy; Marion E Frank
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-26
Journal Detail:
Title:  Chemical senses     Volume:  37     ISSN:  1464-3553     ISO Abbreviation:  Chem. Senses     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-01     Completed Date:  2012-11-28     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  8217190     Medline TA:  Chem Senses     Country:  England    
Other Details:
Languages:  eng     Pagination:  603-12     Citation Subset:  IM    
Department of Oral Health and Diagnostic Sciences, Division of Periodontology, Center for Chemosensory Sciences, School of Dental Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1715, USA.
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MeSH Terms
Acetic Acid / pharmacology*
Amiloride / pharmacology*
Chorda Tympani Nerve / drug effects,  physiology*
Citric Acid / pharmacology*
Electrolytes / chemistry
Hydrogen-Ion Concentration
Sodium Channels / chemistry,  metabolism
Sodium Chloride / pharmacology*
Taste / drug effects,  physiology
Grant Support
Reg. No./Substance:
0/Electrolytes; 0/Sodium Channels; 2609-46-3/Amiloride; 64-19-7/Acetic Acid; 7647-14-5/Sodium Chloride; 77-92-9/Citric Acid

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