| Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible. | |
| | |
MedLine Citation:
|
PMID: 22456378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Radiotherapy, a cornerstone of head and neck cancer treatment, causes substantial morbidity to normal adjoining bone. The authors assessed the radioprotective effect of amifostine therapy on the mineralization of the mandible using micro-computed tomography. They hypothesized that amifostine would safeguard the mandible from radiation-induced disruption of the mineralization process and the associated failure of new bone creation. METHODS: Male Sprague-Dawley rats were randomized into three groups: control (n = 8), radiation therapy (n = 5), and amifostine (n = 8). Animals in the radiation therapy and amifostine groups underwent human bioequivalent radiation of 70 Gy in five fractions to the left hemimandible. Fifty-six days after irradiation, the hemimandibles were harvested for radiomorphometric analyses. RESULTS: Amifostine-treated animals exhibited less alopecia, mucositis, and weight loss in addition to increased cortical density in comparison with those treated with radiation therapy. Bone and tissue mineral densities showed statistically significant improvement in amifostine versus radiation therapy, and no difference was observed between amifostine and control groups. Detailed micro-computed tomographic analysis further demonstrated significant differences in the mineralization profile when comparing radiation therapy and amifostine. Amifostine maintained regions of lower mineralization consistent with the preservation of normal remodeling. CONCLUSIONS: The authors have successfully demonstrated the ability of amifostine pretreatment to protect the natural mineralization profile of bone. This reflects the capacity of amifostine prophylaxis to safeguard the normal surrounding mandible from the impediments of collateral damage imposed by irradiation. Further study can correlate these findings with the potential use of amifostine to prevent the devastating associated morbidities of radiotherapy such as pathologic fractures and osteoradionecrosis. |
| | |
Authors:
|
Catherine N Tchanque-Fossuo; Alexis Donneys; Sagar S Deshpande; Noah S Nelson; Matt J Boguslawski; K Kelly Gallagher; Deniz Sarhaddi; Behdod Poushanchi; Steven A Goldstein; Steven R Buchman |
Related Documents
:
|
20882588 - Metaphyseal fracture healing follows similar biomechanical rules as diaphyseal healing. 7976298 - Inflammatory cells in normal human fracture healing. 17722238 - High concentrations of pamidronate in bone weaken the mechanical properties of intact f... 16413888 - Effects of low-intensity pulsed ultrasound on healing of mandibular fractures: an exper... 14975218 - Urine products of bone breakdown as markers of bone resorption and clinical usefulness ... 7638298 - Ear reconstruction with chondrocutaneous postauricular island flap. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Plastic and reconstructive surgery Volume: 129 ISSN: 1529-4242 ISO Abbreviation: Plast. Reconstr. Surg. Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-03-29 Completed Date: 2012-06-13 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 1306050 Medline TA: Plast Reconstr Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 646e-55e Citation Subset: AIM; IM |
Affiliation:
|
University of Michigan Medical School, the University of Michigan, MI 48109-5340, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amifostine
/
pharmacology* Animals Calcification, Physiologic / drug effects*, radiation effects* Male Mandible / drug effects, pathology, radiation effects*, radiography Microradiography Radiation Dosage Radiation Injuries, Experimental / prevention & control* Radiation-Protective Agents / pharmacology* Rats Rats, Sprague-Dawley Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
|
R01 CA 12587-01/CA/NCI NIH HHS; R01 CA125187-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Radiation-Protective Agents; 20537-88-6/Amifostine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Radiation-Induced Craniofacial Bone Growth Inhibition: Acute and Long-Term Effects on Bone Histopath...
Next Document: Clinical outcomes following supraorbital foraminotomy for treatment of frontal migraine headache.