Document Detail

Amifostine modulation of bleomycin-induced lung injury in rodents.
MedLine Citation:
PMID:  10348257     Owner:  NLM     Status:  MEDLINE    
Bleomycin is an effective anticancer agent whose treatment is limited by severe and potentially fatal pulmonary toxicity. This toxicity, characterized by alveolar inflammation and proliferative fibrosis, is mediated by active oxygen species and may result in disruption of the balance between type 2 pneumocyte apoptosis and fibroblast proliferation. The chemoprotectant activity of amifostine (Ethyol; Alza Pharmaceuticals, Palo Alto, CA/US Bioscience, West Conshohocken, PA) is attributed, in part, to the scavenging of active oxygen species. Therefore, it was of interest to study the effects of amifostine on ameliorating the pulmonary toxicities associated with bleomycin in animals. Studies in hamsters and mice demonstrate that pretreatment with amifostine reduces the pulmonary toxicity induced by bleomycin administration. The results of these preclinical studies suggest that amifostine may be clinically beneficial in reducing the severe pulmonary toxicity associated with bleomycin.
L Nici; P Calabresi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Seminars in oncology     Volume:  26     ISSN:  0093-7754     ISO Abbreviation:  Semin. Oncol.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-04     Completed Date:  1999-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0420432     Medline TA:  Semin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  28-33     Citation Subset:  IM    
Division of Pulmonary/Critical Care Medicine, The Rhode Island Hospital, Providence 02903, USA.
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MeSH Terms
Amifostine / pharmacology*
Antimetabolites, Antineoplastic / adverse effects*
Bleomycin / adverse effects*
Free Radical Scavengers
Lung / drug effects*,  pathology
Mercaptoethylamines / pharmacology
Prodrugs / pharmacology*
Protective Agents / pharmacology*
Pulmonary Fibrosis / chemically induced,  prevention & control
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 0/Free Radical Scavengers; 0/Mercaptoethylamines; 0/Prodrugs; 0/Protective Agents; 11056-06-7/Bleomycin; 20537-88-6/Amifostine; 31098-42-7/WR 1065

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