| Amido-Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro Antisense Potency. | |
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MedLine Citation:
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PMID: 23081931 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Towards the next generation: New LNA analogues based on a cyclic amide structure, termed amido-bridged nucleic acids (AmNAs), have been synthesized. Oligonucleotides modified with these residues showed high nuclease resistance along with high binding affinities towards complementary strands. |
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Authors:
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Aiko Yahara; Ajaya Ram Shrestha; Tsuyoshi Yamamoto; Yoshiyuki Hari; Takashi Osawa; Masaki Yamaguchi; Masaru Nishida; Tetsuya Kodama; Satoshi Obika |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-18 |
Journal Detail:
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Title: Chembiochem : a European journal of chemical biology Volume: - ISSN: 1439-7633 ISO Abbreviation: Chembiochem Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100937360 Medline TA: Chembiochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871 (Japan). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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