Document Detail


Amide Penicillin Wy-12,556: therapeutic activity in animals subjected to repeated bacterial infection.
MedLine Citation:
PMID:  773606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amide penicillin Wy-12,556 and DBED penicillin were studied for their antibacterial effect in CD-1 mice repeatedly infected with Streptococcus pyogenes C203 and/or Staphylococcus aureus Smith. Animals infected with S. aureus Smith failed to show a difference between the therapeutic activity of DBED penicillin and Wy-12,556. Wy-12,556 was significantly more effective than DBED penicillin in protecting the animals challenged repeatedly with S. pyogenes C203. Wy-12,556 provoked a positive transient chemotactic response in uninfected mice. 24 h after intraperitoneal challenge the exudate showed a high neutrophilic count.
Authors:
J A Yurchenco; M W Hopper; T D Vince; G H Warren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemotherapy     Volume:  22     ISSN:  0009-3157     ISO Abbreviation:  Chemotherapy     Publication Date:  1976  
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  232-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Count
Drug Evaluation, Preclinical
Female
Penicillin G Benzathine / pharmacology,  therapeutic use*
Penicillins / pharmacology,  therapeutic use*
Pregnancy
Staphylococcal Infections / drug therapy*
Streptococcal Infections / drug therapy*
Streptococcus pyogenes
Chemical
Reg. No./Substance:
0/Penicillins; 1538-09-6/Penicillin G Benzathine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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