Document Detail


Amicrobial pustulosis of the skin folds and autoimmune erythroblastopenia.
MedLine Citation:
PMID:  21570565     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Amicrobial pustulosis of the skin folds represents a new entity within the spectrum of neutrophilic dermatoses. This disease is characterized by acute onset of pustular lesions in the skin folds, association with an autoimmune disorder, and improvement under systemic corticosteroids. OBSERVATION: A 24-year-old woman had been presenting pustular dermatosis for several months involving the inguinal folds and the scalp. The pustules coalesced to form oozing and crusting plaques. Eczematous lesions were located on the trunk. She also presented macrocytic anemia related to autoimmune erythroblastopenia. Bacteriological culture was negative. Antinuclear antibodies were found with anti-SSA specificity. Histopathological examination of a skin biopsy specimen showed pustules in the epidermis together with an inflammatory dermal infiltrate. Cutaneous direct immunofluorescence testing was negative. The patient responded to systemic corticosteroids. DISCUSSION: Thirty-six cases of amicrobial pustulosis of the skin folds have been reported in the literature. All but two previously reported patients were females with an autoimmune disorder (chiefly systemic lupus erythematosus). The clinical picture is characterized by aseptic pustular lesions of the major and minor skin folds of the scalp and the anogenital area associated with eczematous lesions. Diagnostic criteria have recently been proposed. This disease responds to systemic corticosteroids. We report a new case of amicrobial pustulosis of the skin folds associated with autoimmune erythroblastopenia, which to the best of our knowledge has been described only once in the literature.
Authors:
M Saint-Jean; V Gagey-Caron; F Jossic; S Barbarot; M Hamidou; J-F Stalder
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-30
Journal Detail:
Title:  Annales de dermatologie et de venereologie     Volume:  138     ISSN:  0151-9638     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702013     Medline TA:  Ann Dermatol Venereol     Country:  -    
Other Details:
Languages:  FRE     Pagination:  399-404     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier Masson SAS.
Affiliation:
Service de dermatologie, CHU Hôtel-Dieu, 1, place A.-Ricordeau, 44093 Nantes cedex 01, France.
Vernacular Title:
Pustulose aseptique des plis et érythroblastopénie auto-immune.
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