Document Detail

American ginseng supplementation induces an oxidative stress in postmenopausal women.
MedLine Citation:
PMID:  19828907     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether American ginseng (Panax Quinquefolium) confers antioxidant protection to postmenopausal women at rest and after a mild aerobic exercise session. METHODS: In this double-blinded parallel study, 12 female subjects (age range 55-75) consumed two capsules, containing 500 mg of dry American ginseng whole-root powder, everyday for 4 months, whereas 13 female control subjects of the same age range consumed two placebo capsules. Before and after the supplementation regimen each subject performed 30 minutes of treadmill walking on a 5% grade incline at an estimated 60% of VO(2)max. RESULTS: Ginseng supplementation had no effect on heart rate, blood pressure, plasma blood glucose, or lactate concentration at rest or immediately after exercise tests. The ginseng supplemented group displayed a higher resting plasma glutathione disulfide (GSSG) concentration and lower glutathione (GSH):GSSG ratio, as well as a lower resting total antioxidant content (TAC). Plasma GSSG concentration decreased, whereas the GSH:GSSG ratio and TAC increased after exercise in all subjects. Furthermore, plasma malondialdehyde and urine 8-hydroxydeoxyguanosine concentrations were elevated in the ginseng-supplemented group. Erythrocyte superoxide dismutase and GSH reductase activities were increased after ginseng supplementation. The 30-minute treadmill walking, however, did not alter these changes. CONCLUSIONS: These data suggest that chronic American ginseng supplementation at the given dose can cause an oxidative stress in postmenopausal women, as reflected by the elevated oxidative damage markers and the increased erythrocyte antioxidant enzyme activity.
Jonathan R Dickman; Ryan T Koenig; Li Li Ji
Related Documents :
22817607 - Randomized controlled trial of postoperative exercise rehabilitation program after lumb...
22477417 - Supervised and home-based exercise training for patients with intermittent claudication.
22341377 - Aerobic exercise training during pregnancy reduces depressive symptoms in nulliparous w...
22610907 - Effect of exercise on blood pressure in type 2 diabetes: a randomized controlled trial.
23928377 - Late-onset exercise in female rat offspring ameliorates the detrimental metabolic impac...
7805677 - Prediction of individual oxygen uptake on-step transients from frequency responses.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  28     ISSN:  1541-1087     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-10-15     Completed Date:  2010-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-28     Citation Subset:  IM    
Department Of Kinesiology, University Of Wisconsin - Madison, Madison, Wisconsin, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antioxidants / metabolism*
Deoxyguanosine / analogs & derivatives,  urine
Dietary Supplements
Double-Blind Method
Erythrocytes / enzymology,  metabolism
Exercise / physiology*
Glutathione / blood*
Glutathione Disulfide / blood*
Glutathione Reductase / blood
Malondialdehyde / blood
Middle Aged
Oxidative Stress*
Panax / adverse effects*
Plant Preparations / adverse effects*
Plant Roots
Superoxide Dismutase / blood
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 0/Antioxidants; 0/Plant Preparations; 27025-41-8/Glutathione Disulfide; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; 961-07-9/Deoxyguanosine; EC Dismutase; EC Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Consumption, Perceptions and Knowledge of Soy among Adults with Type 2 Diabetes.
Next Document:  Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ...