| American Leishmania spp: formycin B treatment of cutaneous leishmaniasis in mice. | |
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MedLine Citation:
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PMID: 3614989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using foot-pad infection of female C57BL/6, DBA/2J and NMRI-IVIC mice as an animal model for American cutaneous leishmaniasis (ACL), we evaluated the inhibitory effect of Formycin B (FoB) on the infection produced by 7 different Leishmania isolates. When treatment was initiated some days, or even some weeks, after infection a significant leishmanistatic effect was detected on mice infected with all Leishmania isolates, which reached 30-55 weeks for some isolates. The optimal dose schedule was 1.25 mg/kg body weight/day, injected intraperitoneally for 20 consecutive days. Significant differences in the sensitivity of various Leishmania spp. to FoB were found, either in vivo, or in vitro where a high [3H]FoB incorporation rate was found only for certain Leishmania isolates. The low toxicity of this drug and the sensitivity of the 7 Leishmania isolates tested suggest that FoB could be useful in the treatment of ACL. |
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Authors:
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T Rojas; J L Avila |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Parasitology Volume: 94 ( Pt 3) ISSN: 0031-1820 ISO Abbreviation: Parasitology Publication Date: 1987 Jun |
Date Detail:
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Created Date: 1987-08-28 Completed Date: 1987-08-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401121 Medline TA: Parasitology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 467-74 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibiotics, Antineoplastic / therapeutic use* Cricetinae Female Formycins / therapeutic use* Leishmania / drug effects Leishmania braziliensis / drug effects Leishmania mexicana / drug effects Leishmaniasis / drug therapy* Mesocricetus Mice Mice, Inbred C57BL Mice, Inbred DBA |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Formycins; 13877-76-4/formycin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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