Document Detail

American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
MedLine Citation:
PMID:  440824     Owner:  NLM     Status:  MEDLINE    
There is an increased risk of congenital heart disease and cleft palate among the offspring of women with epilepsy, most of whom are on anticonvulsants. Part of this increase may be caused by phenytoin. The risk of all abnormalities in these infants appears to be about 4% to 5%, which is approximately double the rate of malformations in the general population. There appears to be an ill-defined "syndrome" associated with fetal exposure to hydantoin, although it has not been proven to be caused by the drug. The risk of this "syndrome" is of unknown magnitude, but it is probably less than 10%. The significance to a given child of the abnormalities in this "syndrome" is not predictable at this time.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  63     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-07-28     Completed Date:  1979-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  331-3     Citation Subset:  AIM; IM    
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MeSH Terms
Abnormalities, Drug-Induced / etiology*
Anticonvulsants / adverse effects*,  therapeutic use
Cleft Lip / chemically induced
Cleft Palate / chemically induced
Epilepsy / drug therapy
Heart Defects, Congenital / chemically induced
Hydantoins / adverse effects
Infant, Newborn
Mental Retardation / chemically induced
Phenobarbital / adverse effects
Pregnancy Complications / drug therapy*
Trimethadione / adverse effects
Reg. No./Substance:
0/Anticonvulsants; 0/Hydantoins; 127-48-0/Trimethadione; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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