Document Detail


Amenorrhea-galactorrhea, hyperprolactinemia, and suprasellar pituitary enlargement as presenting features of primary hypothyroidism.
MedLine Citation:
PMID:  6700889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two women who presented with amenorrhea-galactorrhea and hyperprolactinemia associated with x-ray evidence of pituitary enlargement and suprasellar extension were found to have primary hypothyroidism. Resolution of the pituitary enlargement and galactorrhea occurred after thyroid hormone replacement. Both women spontaneously ovulated and conceived, and normal pregnancies resulted. Amenorrhea, galactorrhea, and/or pituitary enlargement may be the principal manifestations of primary hypothyroidism. In such patients, it is imperative that primary hypothyroidism be excluded before drug or surgical therapy for presumed prolactinoma is undertaken. When these findings are due to primary hypothyroidism, thyroid hormone replacement alone is adequate therapy.
Authors:
T R Groff; B L Shulkin; R D Utiger; L M Talbert
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  63     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-03-27     Completed Date:  1984-03-27     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  86S-89S     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amenorrhea / etiology*
Female
Galactorrhea / etiology*
Humans
Hypertrophy
Hypothyroidism / blood,  complications*,  diagnosis,  radiography
Lactation Disorders / etiology*
Pituitary Gland / pathology*,  radiography
Pregnancy
Prolactin / blood*
Grant Support
ID/Acronym/Agency:
AM26112/AM/NIADDK NIH HHS; RR46/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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