| Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats. | |
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MedLine Citation:
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PMID: 21235594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Glycyrrhizin is the main water-soluble constituent of the root of liquorice (Glycyrrhiza glabra). The study investigates the effect of glycyrrhizin on streptozotocin (STZ)-induced diabetic changes and associated oxidative stress, including haemoglobin-induced free iron-mediated oxidative reactions. METHODS: Male Wistar rats were grouped as normal control, STZ-induced diabetic control, normal treated with glycyrrhizin, diabetic treated with glycyrrhizin and diabetic treated with a standard anti-hyperglycaemic drug, glibenclamide. Different parameters were studied in blood and tissue samples of the rats. KEY FINDINGS: Glycyrrhizin treatment improved significantly the diabetogenic effects of STZ, namely enhanced blood glucose level, glucose intolerant behaviour, decreased serum insulin level including pancreatic islet cell numbers, increased glycohaemoglobin level and enhanced levels of cholesterol and triglyceride. The treatment significantly reduced diabetes-induced abnormalities of pancreas and kidney tissues. Oxidative stress parameters, namely, serum superoxide dismutase, catalase, malondialdehyde and fructosamine in diabetic rats were reverted to respective normal values after glycyrrhizin administration. Free iron in haemoglobin, iron-mediated free radical reactions and carbonyl formation in haemoglobin were pronounced in diabetes, and were counteracted by glycyrrhizin. Effects of glycyrrhizin and glibenclamide treatments appeared comparable. CONCLUSION: Glycyrrhizin is quite effective against hyperglycaemia, hyperlipidaemia and associated oxidative stress, and may be a potential therapeutic agent for diabetes treatment. |
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Authors:
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Subhrojit Sen; Moumita Roy; Abhay Sankar Chakraborti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 63 ISSN: 2042-7158 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-17 Completed Date: 2011-06-01 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 287-96 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. JPP © 2011 Royal Pharmaceutical Society. |
Affiliation:
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Department of Biophysics, Molecular Biology & Bioinformatics, University College of Science, University of Calcutta, Acharyya Prafulla Chandra Road, Kolkata, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Catalase / blood, metabolism Cholesterol / blood, metabolism Diabetes Mellitus, Experimental / blood, drug therapy*, metabolism*, pathology Free Radicals / metabolism Fructosamine / blood, metabolism Glucose Intolerance Glyburide / pharmacology Glycyrrhizic Acid / pharmacology* Hemoglobin A, Glycosylated / metabolism Hemoglobins / metabolism Hyperglycemia / drug therapy Hyperlipidemias / drug therapy Insulin / blood, metabolism Islets of Langerhans / drug effects, metabolism Kidney / drug effects, pathology Male Malondialdehyde / blood, metabolism Oxidative Stress / drug effects Pancreas / drug effects, pathology Rats Rats, Wistar Superoxide Dismutase / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Free Radicals; 0/Hemoglobin A, Glycosylated; 0/Hemoglobins; 10238-21-8/Glyburide; 11061-68-0/Insulin; 1405-86-3/Glycyrrhizic Acid; 4429-04-3/Fructosamine; 542-78-9/Malondialdehyde; 57-88-5/Cholesterol; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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