| Ameliorative effects of Cnidoscolus aconitifolius on alloxan toxicity in Wistar rats. | |
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MedLine Citation:
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PMID: 21327141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Diabetes has been associated with several complications occasioned by oxidative stress. Thus, in treatment of the condition, these complications must also be taken into consideration. This study evaluates the effect of Cnidoscolus aconitifolius complications of diabetes induced by alloxan, on haematology and sperm morphometry using the Wistar rats. METHODS: Diabetes was induced in 25 rats using alloxan. The diabetic rats were then divided into five groups B-F consisting of five rats per group. Groups C-E were administered with 100 mg/kg, 500 mg/kg and 1000 mg/kg of ethanolic leaves extract of Cnidoscolus aconitifolius, respectively, for four weeks post treatment with alloxan, while group F received Chlorpropamide (Diabenes®, Pfizer). The diabetic rats in group B were not treated while group A served as the non diabetic control. RESULT: Following treatment with alloxan, there was anaemia, thrombocytopenia and leucopenia, while the sperm count, motility and live/dead ratio were significantly reduced. Sperm morphological abnormalities and erythrocyte osmotic fragility also increased significantly. Following treatment of alloxan treated-rats with the extract, there were significant increases in the PCV, RBC, Hb, WBC, MCV and the platelet values. Erythrocyte osmotic fragility, sperm count, motility and live/dead ratio also improved significantly. CONCLUSION: Cnidoscolus aconitifolius extract was found to ameliorate the effects of alloxan induced diabetes on the haematology but not on the abnormal sperm morphometry in rats. |
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Authors:
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O I Azeez; A A Oyagbemi; M O Oyeyemi; A A Odetola |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: African health sciences Volume: 10 ISSN: 1729-0503 ISO Abbreviation: Afr Health Sci Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-04-27 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 101149451 Medline TA: Afr Health Sci Country: Uganda |
Other Details:
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Languages: eng Pagination: 283-91 Citation Subset: IM |
Affiliation:
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Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria. odunayo.azeez@mail.ui.edu.ng |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alloxan Animals Blood Cells / drug effects*, physiology Blood Glucose / metabolism Chlorpropamide / therapeutic use Diabetes Mellitus, Experimental / chemically induced, drug therapy, metabolism* Euphorbiaceae / chemistry* Hypoglycemic Agents* / pharmacology, therapeutic use Male Osmotic Fragility Oxidative Stress / drug effects Plant Extracts* / pharmacology, therapeutic use Rats Rats, Wistar Spermatozoa / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Plant Extracts; 50-71-5/Alloxan; 94-20-2/Chlorpropamide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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