| Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin. | |
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MedLine Citation:
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PMID: 21046982 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Liver injury was induced in female rats using tamoxifen (TAM). Grape seeds (Vitis vinifera) extract (GSE), black seed (Nigella sativa) extract (NSE), curcumin (CUR) or silymarin (SYL) were orally administered to TAM-intoxicated rats. Liver histopathology of TAM-intoxicated:rats showed pathological changes. TAM-intoxication elicited declines in liver antioxidant enzymes levels (glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase), reduced glutathione (GSH) and GSH/GSSG ratio plus the hepatic elevations in lipid peroxides, oxidized glutathione (GSSG), tumor necrosis factor-alpha (TNF-alpha) and serum liver enzymes; alanine transaminase, aspartate transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase levels. Oral intake of NSE, GSE, CUR or SYL to TAM-intoxicated rats, attenuated histopathological changes and corrected all parameters mentioned above. Improvements were prominent in case of NSE (similarly SYL) > CUR > GSE. Data indicated that NSE, GSE or CUR act as free radicals scavengers and protect TAM-induced liver injury in rats. |
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Authors:
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Hesham A El-Beshbishy; Ahmed M Mohamadin; Ayman A Nagy; Ashraf B Abdel-Naim |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 48 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-11-04 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: India |
Other Details:
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Languages: eng Pagination: 280-8 Citation Subset: IM |
Affiliation:
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Medical Laboratories Technology Dept., Facuty of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia. hesham_elbeshbishy@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Alanine Transaminase / blood Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology Aspartate Aminotransferases / blood Catalase / metabolism Curcumin / administration & dosage, pharmacology* Drug-Induced Liver Injury / blood, etiology, prevention & control* Female Glutathione / metabolism Glutathione Disulfide / metabolism Glutathione Peroxidase / metabolism Glutathione Reductase / metabolism Grape Seed Extract / administration & dosage, pharmacology Lipid Peroxides / metabolism Liver / drug effects, metabolism, pathology Nigella sativa / chemistry Plant Extracts / administration & dosage, pharmacology* Rats Rats, Sprague-Dawley Seeds / chemistry* Superoxide Dismutase / metabolism Tamoxifen / toxicity Tumor Necrosis Factor-alpha / blood Vitis / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Grape Seed Extract; 0/Lipid Peroxides; 0/Plant Extracts; 0/Tumor Necrosis Factor-alpha; 10540-29-1/Tamoxifen; 27025-41-8/Glutathione Disulfide; 458-37-7/Curcumin; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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