| Amelioration of streptozotocin-induced diabetes in the rat by exercise-training: role of muscle glycogenolytic and glycolytic enzyme activity. | |
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MedLine Citation:
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PMID: 6241917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Streptozotocin-induced insulin deficient rats allowed to run at will had significantly (P less than 0.001) lower mean (+/- SEM) plasma glucose levels (12.1 +/- 0.9 vs 22.6 +/- 1.7 mM/l) than did equally insulin deficient sedentary rats. Muscle glycogen phosphorylase and synthase activities were similar in exercise-trained and sedentary diabetic rats, and were unchanged from control values. In contrast, muscle phosphofructokinase activity was reduced (P less than 0.001) in sedentary rats with insulin deficiency, and the defect was significantly reversed (P less than 0.01) when such rats were allowed to run spontaneously. These results are consistent with the view that the ability of exercise-training to attenuate the magnitude of hyperglycemia in streptozotocin-induced insulin deficiency is associated with an effect on a key regulatory enzyme in the glycolytic pathway. |
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Authors:
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M Narimiya; H Chang; S Azhar; G M Reaven |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 16 Suppl 1 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-05-28 Completed Date: 1985-05-28 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 67-70 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus, Experimental / enzymology* Glycogen / metabolism* Glycogen Synthase / metabolism Male Muscles / enzymology* Phosphofructokinase-1 / metabolism Phosphorylases / metabolism Physical Exertion* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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9005-79-2/Glycogen; EC 2.4.1.-/Phosphorylases; EC 2.4.1.11/Glycogen Synthase; EC 2.7.1.11/Phosphofructokinase-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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