Document Detail

Amelioration of steroids and cyclosporine-resistant nephrotic syndrome by pravastatin.
MedLine Citation:
PMID:  17186279     Owner:  NLM     Status:  MEDLINE    
We report the case of a girl with steroids and cyclosporine (CsA) resistant focal segmental glomerulosclerosis (FSGS) whose proteinuria and hypoproteinaemia were dramatically resolved by pravastatin. She had been in a nephrotic condition for 6 years. Prednisolone, pulse methylprednisolone therapy, low-density lipoprotein (LDL) apheresis, CsA, cyclophosphamide and mizoribine (MZR) had proved to be ineffective. She was started on pravastatin for her hyperlipidaemia 6 and a half years from onset, in addition to the baseline therapy, which included CsA; remission of the nephrotic syndrome was unexpectedly attained after 10 months of treatment. The baseline therapy has not been changed since the inclusion of pravastatin. This case suggests that, in patients with hyperlipidaemia, the response to CsA could be restored by lowering cholesterol levels with statins. The decrease of cholesterol levels might have improved the pharmacokinetics of CsA in this patient. Furthermore, the anti-inflammatory and immuno-modulatory effects, recently attributed to statins, may also have been involved in the improvement experienced by our patient.
Shuichi Ito; Hiroyuki Machida; Aya Inaba; Tomonori Harada; Kenichi Okuyama; Tomoko Nakamura; Yukoh Aihara; Shumpei Yokota
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-12-21
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  22     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-07-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  603-6     Citation Subset:  IM    
Children's Medical Center, Yokohama City University Medical Center, Yokohama 232-0024, Japan.
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MeSH Terms
Cyclosporine / pharmacology*
Drug Resistance*
Immunosuppressive Agents / pharmacology*
Nephrotic Syndrome / drug therapy*,  prevention & control
Pravastatin / therapeutic use*
Remission Induction
Steroids / pharmacology*
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Steroids; 59865-13-3/Cyclosporine; 81093-37-0/Pravastatin

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