Document Detail


Amelioration of prolidase deficiency in fibroblasts using adenovirus mediated gene transfer.
MedLine Citation:
PMID:  12503186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prolidase deficiency is an autosomal recessive inherited disease characterized clinically by frequent infections, mental retardation, and various skin lesions. Fundamental treatments for these manifestations have not been established. We performed adenovirus-mediated gene transfer of human prolidase cDNA into fibroblasts from patients with prolidase deficiency. Infection with the adenovirus vector carrying human prolidase cDNA increased prolidase activity in fibroblasts up to approximately 7.5 times of that of normal control fibroblasts. This indicates the feasibility of adenovirus-mediated gene therapy to treat patients with prolidase deficiency in the future.
Authors:
K Ikeda; J Tohyama; S Tsujino; K Sato; T Oono; J Arata; F Endo; N Sakuragawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Japanese journal of human genetics     Volume:  42     ISSN:  0916-8478     ISO Abbreviation:  Jpn. J. Hum. Genet.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  2002-12-30     Completed Date:  2003-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9213239     Medline TA:  Jpn J Hum Genet     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  401-8     Citation Subset:  IM    
Affiliation:
Department of Inherited Metabolic Disease, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenoviridae / genetics*
Cells, Cultured
DNA, Complementary / genetics
Dipeptidases / deficiency*,  genetics*,  metabolism
Female
Fibroblasts / enzymology,  metabolism
Gene Therapy*
Gene Transfer Techniques*
Genes, Recessive
Genetic Vectors
Humans
Metabolism, Inborn Errors / enzymology,  therapy*
RNA, Messenger / genetics,  metabolism
Skin / cytology
Skin Diseases / enzymology,  genetics
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/RNA, Messenger; EC 3.4.13.-/Dipeptidases; EC 3.4.13.9/proline dipeptidase

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