| Amelioration of prolidase deficiency in fibroblasts using adenovirus mediated gene transfer. | |
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MedLine Citation:
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PMID: 12503186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prolidase deficiency is an autosomal recessive inherited disease characterized clinically by frequent infections, mental retardation, and various skin lesions. Fundamental treatments for these manifestations have not been established. We performed adenovirus-mediated gene transfer of human prolidase cDNA into fibroblasts from patients with prolidase deficiency. Infection with the adenovirus vector carrying human prolidase cDNA increased prolidase activity in fibroblasts up to approximately 7.5 times of that of normal control fibroblasts. This indicates the feasibility of adenovirus-mediated gene therapy to treat patients with prolidase deficiency in the future. |
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Authors:
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K Ikeda; J Tohyama; S Tsujino; K Sato; T Oono; J Arata; F Endo; N Sakuragawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Japanese journal of human genetics Volume: 42 ISSN: 0916-8478 ISO Abbreviation: Jpn. J. Hum. Genet. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 2002-12-30 Completed Date: 2003-03-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9213239 Medline TA: Jpn J Hum Genet Country: Japan |
Other Details:
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Languages: eng Pagination: 401-8 Citation Subset: IM |
Affiliation:
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Department of Inherited Metabolic Disease, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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genetics* Cells, Cultured DNA, Complementary / genetics Dipeptidases / deficiency*, genetics*, metabolism Female Fibroblasts / enzymology, metabolism Gene Therapy* Gene Transfer Techniques* Genes, Recessive Genetic Vectors Humans Metabolism, Inborn Errors / enzymology, therapy* RNA, Messenger / genetics, metabolism Skin / cytology Skin Diseases / enzymology, genetics |
| Chemical | |
Reg. No./Substance:
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0/DNA, Complementary; 0/RNA, Messenger; EC 3.4.13.-/Dipeptidases; EC 3.4.13.9/proline dipeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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