Document Detail

Amelioration of effects of severe dietary copper deficiency by food restriction in rats.
MedLine Citation:
PMID:  8249874     Owner:  NLM     Status:  MEDLINE    
To test the effect of food restriction on responses to dietary copper deficiency, male weanling rats were fed two amounts of dietary copper via five dietary-intake regimens ranging from ad libitum to 70% of ad libitum intake. Copper-deficient rats exhibited characteristic signs, including depressed organ copper content, reduced activity of copper-dependent enzymes, enlarged hearts, and anemia. Food restriction attenuated the cardiac enlargement, red blood cell defects, and reduction of superoxide dismutase activity in copper-deficient rats. Mineral and enzyme assays suggested that possible mechanisms for this amelioration are the correction of copper status and/or the improvement of antioxidant status. Also, food restriction depressed serum cholesterol and enhanced cytochrome c oxidase activity in both copper-adequate and copper-deficient rats, which compensated for effects of copper deficiency. A second experiment illustrated that the mortality associated with severe copper deficiency was also inhibited by food restriction.
J T Saari; W T Johnson; P G Reeves; L K Johnson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  58     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1993-12-23     Completed Date:  1993-12-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  891-6     Citation Subset:  AIM; IM    
United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, ND 58202-9034.
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MeSH Terms
Cardiovascular System / physiopathology
Copper / analysis,  deficiency*
Food Deprivation*
Liver / chemistry,  enzymology
Longevity / physiology*
Myocardium / chemistry
Rats, Sprague-Dawley
Zinc / analysis
Reg. No./Substance:
7440-50-8/Copper; 7440-66-6/Zinc

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