| Ameliorating effects and mechanisms of electroacupuncture on gastric dysrhythmia, delayed emptying, and impaired accommodation in diabetic rats. | |
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MedLine Citation:
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PMID: 20093561 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate the effects and mechanisms of electroacupuncture (EA) on gastric accommodation, gastric dysrhythmia, and gastric emptying (GE) in streptozotocin (STZ)-induced diabetic rats. Five experiments were performed in five groups of STZ-induced diabetic rats to study the effects of EA at ST-36 (Zusanli) on gastric slow-wave dysrhythmia, delayed GE and intestinal transit, impaired gastric accommodation, and the mechanisms of EA involving the autonomic and opioidergic pathways. We found the following: 1) EA improved gastric dysrhythmia in the diabetic rats. The normal percentage of slow waves was 55.4 +/- 2.9% at baseline and significantly increased to 69.2 +/- 2.2% with EA (P = 0.01); this effect was blocked by naloxone. 2) EA resulted in a 21.4% increase in GE and 18.2% increase in small intestinal transit in the diabetic rats. 3) EA restored diabetes-induced impairment in gastric accommodation. Gastric accommodation was 0.98 +/- 0.13 ml with sham EA and significantly increased to 1.21 +/- 0.15 ml with EA (P = 0.01), and this effect was blocked by naloxone. 4) EA increased vagal activity assessed by the spectral analysis of the heart rate variability. We concluded that EA at ST-36 improves gastric dysrhythmia, delayed GE and intestinal transit, and impaired accommodation in STZ-induced diabetic rats, and the improvement seems to be mainly mediated via the vagal pathway. EA may have a promising therapeutic potential for diabetic gastroparesis. |
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Authors:
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Jieyun Yin; Jie Chen; Jiande D Z Chen |
Publication Detail:
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Type: Journal Article Date: 2010-01-21 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 298 ISSN: 1522-1547 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G563-70 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Complications / pathology, physiopathology*, therapy* Diabetes Mellitus, Experimental / complications*, physiopathology, therapy Electroacupuncture* Electrocardiography Fasting / physiology Gastric Emptying / physiology Gastrointestinal Motility / physiology* Gastrointestinal Transit / physiology Gastroparesis / etiology, pathology, physiopathology*, therapy* Heart Rate / physiology Male Myoelectric Complex, Migrating / drug effects, physiology Naloxone / pharmacology Rats Rats, Sprague-Dawley Stomach / drug effects, pathology, physiology, physiopathology Vagus Nerve / physiology |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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