| Ameliorated effects of green tea extract on lead induced liver toxicity in rats. | |
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MedLine Citation:
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PMID: 20889321 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In the present study, the effect of green tea extract (GTE) on lead induced toxicity was studied in Sprague-Dawley rats. Four groups of rats were used in the study. Lead and GTE was given orally to the rats with drinking water for 8 weeks. Lead concentration in the digested tissues of liver was detected using atomic absorption spectroscopy. The activities of glutathione-S-transferase (GST) and superoxide dismutase (SOD) were used as markers to evaluate the anti oxidant status of tissues. Lead exposure was found to attenuate the antioxidant potential of liver, which was however augmented when supplemented with green tea extract. Liver enzymes ALT, AST and ALP and serum protein determinations indicated the protective effects of green tea extract. Histopathological studies of liver revealed that supplementation of green tea extract resulted in mild degeneration and congestion of the blood vessels and an enhanced regenerative capacity. |
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Authors:
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E E Mehana; Abdel Raheim M A Meki; Khalid Majid Fazili |
Publication Detail:
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Type: Journal Article Date: 2010-10-14 |
Journal Detail:
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Title: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Volume: 64 ISSN: 1618-1433 ISO Abbreviation: Exp. Toxicol. Pathol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208920 Medline TA: Exp Toxicol Pathol Country: Germany |
Other Details:
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Languages: eng Pagination: 291-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier GmbH. All rights reserved. |
Affiliation:
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Department of Pathology, College of Veterinary Medicine, Alexandria University, Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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