Document Detail


Ameboid cell motility: a model and inverse problem, with an application to live cell imaging data.
MedLine Citation:
PMID:  16997326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this article a mathematical model for ameboid cell movement is developed using a spring-dashpot system with Newtonian dynamics. The model is based on the facts that the cytoskeleton plays a primary role for cell motility and that the cytoplasm is viscoelastic. Based on the model, the inverse problem can be posed: if a structure like a spring-dashpot system is embedded into the living cell, what kind of characteristic properties must the structure have in order to reproduce a given movement of the cell? This inverse problem is the primary topic of this paper. On one side the model mimics some features of the movement, and on the other side, the solution to the inverse problem provides model parameters that give some insight, principally into the mechanical aspect, but also, through qualitative reasoning, into chemical and biophysical aspects of the cell. Moreover, this analysis can be done locally or globally and in different media by using the simplest possible information: positions of the cell and nuclear membranes. It is shown that the model and solution to the inverse problem for simulated data sets are highly accurate. An application to a set of live cell imaging data obtained from random movements of a human brain tumor cell (U87-MG human glioblastoma cell line) then provides an example of the efficiency of the model, through the solution of its inverse problem, as a way of understanding experimental data.
Authors:
Huseyin Coskun; Yi Li; Michael A Mackey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-07-26
Journal Detail:
Title:  Journal of theoretical biology     Volume:  244     ISSN:  0022-5193     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-11-27     Completed Date:  2007-04-11     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  169-79     Citation Subset:  IM    
Affiliation:
School of Mathematics, University of Minnesota, Minneapolis, MN 55455 USA. coskun@umn.edu
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MeSH Terms
Descriptor/Qualifier:
Cell Membrane / physiology
Cell Movement / physiology*
Computational Biology / methods
Cytoskeleton / physiology
Elasticity
Glioblastoma / pathology*
Humans
Image Processing, Computer-Assisted / methods
Models, Biological*
Tumor Cells, Cultured
Viscosity
Grant Support
ID/Acronym/Agency:
CA/GM94801/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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