Document Detail


Ambulatory twenty-four-hour blood pressure measurements in pharmacological studies.
MedLine Citation:
PMID:  2082004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Until a few years ago, only casual blood pressure measurements were used in the diagnosis and treatment of arterial hypertension in clinical practice and in pharmacological studies. The development of portable lightweight devices for 24-h ambulatory blood pressure measurement has proved a substantial step towards reducing the potential pitfalls of casual blood pressure measurements. Ambulatory monitoring of blood pressure can improve pharmacological trials by excluding patients in whom blood pressure is elevated only in the clinic environment, and by increasing the accuracy and reproducibility of blood pressure values. Twenty-four-hour blood pressure measurement has great advantages for trials investigating the time-course of a particular drug, since the 24-h blood pressure rhythm is fully monitored. However, internationally accepted normal values for 24-h blood pressure measurements are required, and the interpretation of results obtained with this method needs to be standardized before the technique can be routinely used in antihypertensive drug trials.
Authors:
B Weisser; T Mengden; W Vetter
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  8     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-05-03     Completed Date:  1991-05-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S87-92     Citation Subset:  IM    
Affiliation:
Universitätsspital Zürich, Medizinische Poliklinik, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / therapeutic use*
Blood Pressure / physiology
Blood Pressure Monitors / utilization*
Clinical Trials as Topic*
Drug Evaluation / methods*
Humans
Hypertension / drug therapy*
Reference Values
Research Design
Chemical
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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