| Ambulatory quantitative waking and sleeping cough assessment in patients with cystic fibrosis. | |
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MedLine Citation:
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PMID: 21459051 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Although cough is a commonly reported symptom, objective quantitation of cough during normal activity has not been performed in patients with CF. METHODS: An ambulatory device was used to characterize cough over 24hours. Pulmonary function and subject-reported coughing were also assessed. RESULTS: Patients included 19 clinically stable adults with CF (males:females=10:9; median age [range]=26 [19-57] years; median %-predicted FEV(1) [range]=65 [44-106]%). Median [range] cough rate was 27 [13-66] coughs/hour, with values while awake of 41 [20-102] and while asleep of 2 [0.1-7] (p<0.0001, Wilcoxon signed-rank test). Subjective reporting was consistent with objective data for wake-sleep differences, but correlated poorly with objective waking cough rate. CONCLUSIONS: Outpatient cough quantitation in patients with CF is feasible, indicates frequent coughing even during clinical stability, and may be useful in therapeutic trials in CF. |
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Authors:
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Eitan Kerem; Michael Wilschanski; Nilsen L Miller; Thea Pugatsch; Tali Cohen; Hannah Blau; Joseph Rivlin; David Shoseyov; Allen Reha; Scott Constantine; Temitayo Ajayi; Samit Hirawat; Gary L Elfring; Stuart W Peltz; Langdon L Miller |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-31 |
Journal Detail:
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Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Volume: - ISSN: 1873-5010 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128966 Medline TA: J Cyst Fibros Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Hadassah Hebrew University Medical Center, Jerusalem, Israel 91240. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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