Document Detail

Ambulatory pH monitoring of gastro-oesophageal reflux in "morning dipper" asthmatics.
MedLine Citation:
PMID:  3146369     Owner:  NLM     Status:  MEDLINE    
A causal relation between gastro-oesophageal reflux and nocturnal asthma has been postulated. Forty four adult asthmatics underwent ambulatory monitoring of their oesophageal pH over 24 hours to find out if there was such a relation. Of these 21 showed significant "morning dipping" in which the peak expiratory flow falls during the night. Asthmatics with morning dipping had a history of nocturnal wheeze and a higher incidence of reflux symptoms, but measurement of oesophageal pH showed no significant difference in the amount or pattern of reflux when compared with "non-dippers." Overall, 15 asthmatics had gastro-oesophageal reflux, and these participated in a randomised, double blind crossover trial of ranitidine versus placebo. No significant difference was found in the peak expiratory flow rates or subjective evaluation of well being of the patients.
R A Nagel; P Brown; W H Perks; R S Wilson; G D Kerr
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  297     ISSN:  0959-8138     ISO Abbreviation:  BMJ     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1371-3     Citation Subset:  AIM; IM    
Royal Shrewsbury Hospital, Shropshire.
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MeSH Terms
Ambulatory Care
Asthma / etiology*,  physiopathology
Clinical Trials as Topic
Double-Blind Method
Esophagus / physiopathology
Gastroesophageal Reflux / complications*,  drug therapy,  physiopathology
Hydrogen-Ion Concentration
Middle Aged
Monitoring, Physiologic
Peak Expiratory Flow Rate
Random Allocation
Ranitidine / therapeutic use
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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