| Ambulatory pH monitoring of gastro-oesophageal reflux in "morning dipper" asthmatics. | |
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MedLine Citation:
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PMID: 3146369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A causal relation between gastro-oesophageal reflux and nocturnal asthma has been postulated. Forty four adult asthmatics underwent ambulatory monitoring of their oesophageal pH over 24 hours to find out if there was such a relation. Of these 21 showed significant "morning dipping" in which the peak expiratory flow falls during the night. Asthmatics with morning dipping had a history of nocturnal wheeze and a higher incidence of reflux symptoms, but measurement of oesophageal pH showed no significant difference in the amount or pattern of reflux when compared with "non-dippers." Overall, 15 asthmatics had gastro-oesophageal reflux, and these participated in a randomised, double blind crossover trial of ranitidine versus placebo. No significant difference was found in the peak expiratory flow rates or subjective evaluation of well being of the patients. |
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Authors:
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R A Nagel; P Brown; W H Perks; R S Wilson; G D Kerr |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: BMJ (Clinical research ed.) Volume: 297 ISSN: 0959-8138 ISO Abbreviation: BMJ Publication Date: 1988 Nov |
Date Detail:
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Created Date: 1989-03-23 Completed Date: 1989-03-23 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8900488 Medline TA: BMJ Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1371-3 Citation Subset: AIM; IM |
Affiliation:
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Royal Shrewsbury Hospital, Shropshire. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ambulatory Care Asthma / etiology*, physiopathology Clinical Trials as Topic Double-Blind Method Esophagus / physiopathology Gastroesophageal Reflux / complications*, drug therapy, physiopathology Humans Hydrogen-Ion Concentration Middle Aged Monitoring, Physiologic Peak Expiratory Flow Rate Random Allocation Ranitidine / therapeutic use Time Factors |
| Chemical | |
Reg. No./Substance:
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66357-35-5/Ranitidine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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