| Ambulatory oxygen improves the effectiveness of pulmonary rehabilitation in selected patients with chronic obstructive pulmonary disease. | |
| | |
MedLine Citation:
|
PMID: 22452975 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The effect of ambulatory oxygen use during pulmonary rehabilitation (PR) has not yet been clearly established, but many studies have shown benefit from oxygen acutely. Two small studies to date demonstrated no clear benefit when oxygen was used in patients who desaturated on exertion during a PR programme. One study showed the benefit of using oxygen during PR in patients who were normoxic at rest and desaturated to a minimum of 88% on exertion. We conducted a single-blind, randomised controlled trial comparing PR undertaken either with or without ambulatory oxygen, in those with demonstrable benefit from oxygen at baseline. Subjects from three PR services were recruited who, during baseline assessment, desaturated by more than 4% and to less than 90% on exertion, and walked 10% or more further with ambulatory oxygen on endurance shuttle walk test. Patients were randomised to either room air or oxygen via portable cylinder, titrated to optimise pulse oxygen saturation but up to a maximum flow rate of 6 L/min. All patients then completed a twice weekly, 6- to 7-week PR programme. Data were analysed as per protocol. Totally 51 patients completed the study. At the end of PR, both groups improved with PR, with patients in the oxygen group demonstrating a highly statistically significantly greater mean improvement in endurance walking distance than the controls, 490 m (95% confidence interval 228-750; p ≤ 0.001), as well as clinically, although not statistically, significant changes in quality of life. The use of ambulatory oxygen during a 6- to 7-week PR programme greatly improved endurance walking distance in patients who desaturated on exertion with a positive acute response to ambulatory oxygen at baseline. |
| | |
Authors:
|
F Dyer; J Callaghan; K Cheema; J Bott |
Related Documents
:
|
1985535 - Intra-abdominal abscess in regional enteritis. 7372065 - Hla antigens in ulcerative colitis and crohn's disease in israel. 17334865 - Factors predicting postoperative infectious complications and early induction of inflam... 14605565 - Factors associated with ileal mucosal morphology and inflammation in patients with ilea... 19935775 - A phase i study of telomerase-specific replication competent oncolytic adenovirus (telo... 3136635 - Flecainide for supraventricular tachycardia in children. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-27 |
Journal Detail:
|
Title: Chronic respiratory disease Volume: - ISSN: 1479-9731 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101197408 Medline TA: Chron Respir Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
The Respiratory Care Team, Surrey Community Health, Chertsey, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nonpharmacological interventions for managing respiratory symptoms in lung cancer.
Next Document: Motivations for participating in a clinical trial on an avian influenza vaccine.