Document Detail


Ambulatory oximetry fails to predict survival in COPD with mild-to-moderate hypoxaemia.
MedLine Citation:
PMID:  23126259     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SUMMARY AT A GLANCE: Long-term oxygen therapy improves survival in COPD, although the ability of oxygenation parameters to predict outcomes has not been studied. We studied subjects with mild-to-moderate resting hypoxaemia, failing to meet standard qualifying criteria for long-term oxygen therapy. Neither P(a) O(2) nor partial 24-hour oxygen saturations below 90% effectively predicted clinical outcomes. ABSTRACT: Background and objective:  Although long-term oxygen therapy is one of few treatments known to improve survival in COPD, no patient subgroup likely to derive benefit has been identified in over thirty years. We assessed the prognostic value of point measurement of P(a) O(2) and proportion of ambulatory oximetry with saturations below 90% in this context. Methods:  Subjects were community-living patients with COPD and P(a) O(2) 56-70mmHg when stable. Baseline assessments included clinical, physiological and laboratory assessments, as well as 24-hour ambulatory oximetry. Patients were followed to death from any cause, first exacerbation and first admission. Results:  Despite poor survival overall, there was no significant difference in prognosis between mildly hypoxaemic and moderately hypoxaemic patients. There were also no significant differences for secondary endpoints (exacerbation and hospital admission). On multivariate analysis, trends were observed towards improved survival with higher P(a) O(2) and greater proportion of ambulatory oximetry below 90%. Conclusions:  Neither resting P(a) O(2) nor proportion of ambulatory oximetry below 90% saturation effectively predicted survival in COPD. © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Authors:
James McCracken Trauer; Chelsea A Gielen; Ali Aminazad; Christopher L Steinfort
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-5
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Affiliation:
Department of Respiratory and Sleep Medicine, Western Health, Victoria Hospital Admissions Risk Program, Barwon Health, Victoria Department of Respiratory and Sleep Medicine, Eastern Health, Victoria Department of Respiratory and Sleep Medicine, Barwon Health, Victoria.
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