Document Detail

Ambulatory oesophageal pH monitoring: a comparison between antimony, ISFET, and glass pH electrodes.
MedLine Citation:
PMID:  20009939     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Ambulatory oesophageal pH-impedance monitoring is a widely used test to evaluate patients with reflux symptoms. Several types of pH electrodes are available: antimony, ion sensitive field effect transistor (ISFET), and glass electrodes. These pH electrodes have not been compared directly, and it is uncertain whether these different types of pH electrodes result in similar outcome. METHODS: In an in-vitro model the response time, sensitivity, and drift of an antimony, ISFET, and glass pH electrode were assessed simultaneously after calibration at 22 degrees C and at 37 degrees C. All measurements were performed at 37 degrees C and repeated five times with new catheters of each type. Fifteen patients with reflux symptoms underwent 24-h pH monitoring off PPI therapy using antimony, ISFET, and glass pH electrodes simultaneously. RESULTS: After calibration at 22 degrees C, pH electrodes had similar response times, sensitivity and drift. In contrast to glass electrodes, antimony electrodes performed less accurately after calibration at 37 degrees C than after calibration at 22 degrees C. Calibration temperature did not affect ISFET electrodes significantly. During in-vivo experiments, significant differences were found in acid exposure times derived from antimony (4.0+/-0.8%), ISFET (5.7+/-1.1%), and glass pH electrodes (9.0+/-1.7%). CONCLUSION: In vitro, antimony and glass pH electrodes are affected by different buffer components and temperature, respectively. In vivo, significant higher acid exposure times are obtained with glass electrodes compared with antimony and ISFET pH electrodes. ISFET electrodes produce stable in-vitro measurements and result in the most accurate in-vivo measurements of acid exposure time.
Gerrit J M Hemmink; Bas L A M Weusten; Jac Oors; Albert J Bredenoord; Robin Timmer; André J P M Smout
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  22     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-15     Completed Date:  2010-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  572-7     Citation Subset:  IM    
Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands.
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MeSH Terms
Esophageal pH Monitoring / instrumentation*,  standards
Gastric Acid / metabolism
Gastric Juice / metabolism
Gastroesophageal Reflux / diagnosis*,  metabolism
Hydrogen-Ion Concentration
Middle Aged
Monitoring, Ambulatory / instrumentation*,  methods*,  standards
Reproducibility of Results
Sensitivity and Specificity
Transistors, Electronic
Reg. No./Substance:
0/Buffers; 7440-36-0/Antimony

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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