Document Detail


Ambulatory combined pH, bile and manometric monitoring of the oesophagus in asymptomatic healthy volunteers.
MedLine Citation:
PMID:  15522046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: With the development of sophisticated equipment ambulatory studies of oesophageal motor function, pH and bilirubin have gained in popularity. The aim of the study was to present reference values for combined 24 h pH, bilirubin and manometric measurements of the oesophagus. METHODS: Twenty-six (15 male) healthy volunteers without symptoms of gastro-oesophageal reflux underwent a 24-h ambulatory oesophageal combined three-channel pressure, acid and bilirubin detection. RESULTS: The subjects were studied for a median of 20 h (16-22). The median per cent time with pH < 4 for the whole measured time was 3.1 (0.8-14; 5 and 95 percentiles). Bile was detected for a median of 0.05% (0.0-8.5; 5 and 95 percentiles) of the time. Eighty-one per cent of the contractions were peristaltic, 55% of which were complete. Of these, 53% had a pressure over 30 mmHg at all three pressure points, giving an efficient peristalsis in a median of 29% (13-46; 5 and 95 percentiles) of all registered contractile patterns. No difference between the genders could be observed. CONCLUSIONS: This study provides normative data for ambulatory oesophageal manometry, pH and bilirubin studies that can be used for comparing with patients with disease.
Authors:
Jacob Freedman; Madeleine Lindqvist; Anders Melcher; Lars Granström; Erik Näslund
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  24     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-03     Completed Date:  2005-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  368-73     Citation Subset:  IM    
Affiliation:
Division of Surgery, Karolinska Institute Danderyd Hospital, Stockholm, Sweden. jacob.freedman@kir.ds.sll.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Bile / chemistry*
Catheterization / instrumentation,  methods*,  standards
Esophagus / chemistry*,  physiology*
Female
Gastroesophageal Reflux / diagnosis,  physiopathology
Humans
Hydrogen-Ion Concentration
Male
Manometry / instrumentation,  methods*,  standards
Middle Aged
Monitoring, Ambulatory / instrumentation,  methods*,  standards
Pressure
Reference Values
Reproducibility of Results
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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